- Dario Sala - FCD
- Shea Salinas - SJ
- Alvaro Sanchez - FCD
- Ramon Sanchez - SJ
- Tony Sanneh - LA
- Maicon Santos - CHV
- Amadou Sanyang - TFC
- Marcelo Saragosa - CHV
- Kwame Sarkodie - COL
- Luke Sassano - NY
- Josh Saunders - LA
- Guillermo Barros Schelotto - CLB
- Kenny Schoeni - CLB
- Ross Schunk - COL
- Zach Scott - SEA
- Scott Sealy - SJ
- Gonzalo Segares - CHI
- Chris Seitz - RSL
- Adriano Serioux - TFC
- Israel Sesay - LA
- Brek Shea - FCD
- Clyde Simms - DC
- Jamie Smith - COL
- Jarrod Smith - SEA
- Johann Smith - TFC
- Khano Smith - NY
- Davide Somma - SJ
- Bakary Soumare - CHI
- Kevin Souter - KC
- Seth Stammler - NY
- Bojan Stepanovic - CHV
- Nathan Sturgis - SEA
- Claudio Suarez - CHV
- Greg Sutton - TFC
- Danny Szetela - DC